Human blood eosinophils produce and secrete interleukin 4
نویسندگان
چکیده
منابع مشابه
Human eosinophils synthesize and secrete interleukin-6, in vitro.
Using the technique of in situ hybridization, we have shown that resting, unstimulated, human peripheral blood eosinophils, obtained from subjects with greater than 8% eosinophilia, transcribe and translate messenger RNA (mRNA) for interleukin-6 (IL-6). After incubation for 24 hours in culture medium alone, approximately 19% of eosinophils were positive for IL-6 mRNA. This may be a reflection o...
متن کاملHuman eosinophils secrete preformed, granule-stored interleukin-4 through distinct vesicular compartments.
Secretion of interleukin-4 (IL-4) by leukocytes is important for varied immune responses including allergic inflammation. Within eosinophils, unlike lymphocytes, IL-4 is stored in granules (termed specific granules) and can be rapidly released by brefeldin A (BFA)-inhibitable mechanisms upon stimulation with eotaxin, a chemokine that activates eosinophils. In studying eotaxin-elicited IL-4 secr...
متن کاملHuman eosinophils produce neurotrophins and secrete nerve growth factor on immunologic stimuli.
Neurotrophins, such as nerve growth factor (NGF) and neurotrophin-3 (NT-3), are essential for development, function, and survival of peripheral sympathetic and sensory neurons. Most eosinophilic leukocytes in the human body are localized in mucosal tissues; however, the roles of eosinophils in human diseases are not fully understood. We found that human eosinophils constitutively express messen...
متن کاملHuman Platelets Secrete Chemotactic Activity for Eosinophils
Thrombin-stimulated platelets liberate factors that induce chemotaxis of eosinophils and raise their cytosolic Ca2+ content ([Ca2+],). The sources of this activity are the denseand a-granules because inhibition of prostaglandin endoperoxide/thromboxane A2 formation and the platelet-activating factor receptor-antagonist WEB 2086 have no effect. Platelets from patients with Storage-Pool Deficienc...
متن کاملHuman platelets secrete chemotactic activity for eosinophils.
Thrombin-stimulated platelets liberate factors that induce chemotaxis of eosinophils and raise their cytosolic Ca2+ content ([Ca2+]i). The sources of this activity are the dense- and alpha-granules because inhibition of prostaglandin endoperoxide/thromboxane A2 formation and the platelet-activating factor receptor-antagonist WEB 2086 have no effect. Platelets from patients with Storage-Pool Def...
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ژورنال
عنوان ژورنال: Respiratory Medicine
سال: 1996
ISSN: 0954-6111
DOI: 10.1016/s0954-6111(96)90098-0